Lean Pork and Muscle Protein Synthesis After Resistance Exercise: A Study
A new study from the University of Illinois at Urbana-Champaign, published in the American Journal of Clinical Nutrition, challenges conventional wisdom regarding the impact of fat content on muscle protein synthesis after resistance exercise. Researchers discovered that consuming lean pork post-workout resulted in significantly greater muscle growth compared to consuming high-fat pork, even when both sources provided the same amount of protein. This finding suggests that the composition of whole foods, beyond simply protein quantity, plays a crucial role in optimizing muscle recovery and growth.
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Official guidance: NIH — official guidance for type meat supercharges muscle growth workouts Update 2025
The Impact of Fat Content on Muscle Protein Synthesis

The research team, led by Professor Nicholas Burd and graduate student Žan Zupančič, investigated how different types of pork influenced muscle response to weight training. Sixteen physically active adults participated in the study, undergoing resistance exercises (leg presses and leg extensions) followed by the consumption of either a high-fat pork burger, a lean pork burger, or a carbohydrate drink. All pork burgers contained the same amount of protein. To accurately track muscle-protein synthesis, participants were infused with isotope-labeled amino acids, enabling researchers to monitor the incorporation of these amino acids into muscle tissue.
Blood samples were collected throughout the experiment to measure circulating amino acid levels, and muscle biopsies were taken before and after the two-hour infusion and again five hours after meal consumption. The results indicated that while amino acid levels in the blood increased after pork consumption compared to the carbohydrate drink, the lean pork burger led to the most substantial increase in total and essential amino acids. More importantly, the rate of muscle-protein synthesis was significantly higher in those who consumed lean pork compared to those who consumed high-fat pork, suggesting that the fat content in the high-fat pork blunted the muscle-building response. This was contrary to some previous studies that indicated fattier foods, such as whole eggs and salmon, enhanced post-exercise muscle-protein synthesis compared with lower fat foods.
Whole Foods vs. Processed Blends: A Growing Body of Evidence

Professor Burd’s research builds upon previous findings that highlight the superiority of whole foods over processed alternatives in stimulating muscle growth. Earlier work demonstrated that consuming whole eggs after weight training led to greater muscle-protein synthesis compared to consuming the same amount of protein from egg whites alone. Similarly, eating salmon produced a stronger muscle-building response compared to a processed blend containing identical nutrients in the same proportions. These observations suggest that the complex matrix of nutrients and other compounds present in whole foods may synergistically enhance muscle protein synthesis in ways that processed foods cannot replicate.
The current study further reinforces this concept by demonstrating that even within the same type of meat (pork), variations in fat content can significantly alter the muscle-building response. This suggests that the form and processing of food matter significantly when considering post-exercise recovery and muscle growth. The researchers collaborated with the University of Illinois Meat Science Laboratory to create pork patties with precisely defined fat levels, ensuring that the only variable being tested was fat content. This meticulous approach strengthens the validity of the study’s conclusions.
Implications for Athletes and Fitness Enthusiasts
The findings of this study have important implications for athletes, fitness enthusiasts, and anyone seeking to optimize muscle growth through dietary strategies. While protein intake remains a cornerstone of muscle building, the type and composition of protein sources appear to be equally important. Choosing lean protein sources, such as lean pork, over higher-fat alternatives may lead to more efficient muscle protein synthesis after resistance exercise. This does not necessarily mean eliminating all fats from the diet, as some fats are essential for overall health and hormone production. However, it suggests that prioritizing lean protein sources in the post-workout meal may be advantageous for maximizing muscle growth.
The study also highlights the importance of considering whole foods over processed supplements whenever possible. While protein supplements can be a convenient option for some individuals, whole foods offer a wider range of nutrients and bioactive compounds that may contribute to a more robust muscle-building response. Further research is needed to fully elucidate the mechanisms underlying these effects, but the growing body of evidence suggests that a holistic approach to nutrition, focusing on whole, minimally processed foods, is optimal for supporting muscle growth and overall health.
Future Research Directions
While this study provides valuable insights into the impact of fat content on muscle protein synthesis, further research is needed to explore the underlying mechanisms and to investigate the effects of other dietary factors. Future studies could examine the role of specific fatty acids, the impact of different cooking methods, and the interaction between protein, fat, and carbohydrate intake on muscle growth. Additionally, research is needed to determine whether these findings generalize to other populations, such as older adults or individuals with different training backgrounds.
Ultimately, a deeper understanding of the complex interplay between nutrition and muscle physiology will enable the development of more effective dietary strategies for optimizing muscle growth, recovery, and overall health.
In conclusion, the 2025 study from the University of Illinois at Urbana-Champaign demonstrates that lean pork promotes muscle growth more effectively after workouts than high-fat pork, even with identical protein levels. This finding underscores the importance of considering the composition of whole foods, not just protein quantity, when optimizing muscle recovery and growth.
Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Consult a qualified healthcare professional before making health decisions.
Sources: Information based on credible sources and industry analysis.
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